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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sackel, Ben | C | Reidsville Red Sox | 21 | 07/15/1982 | Chicago | USA | Right | Right | 6' 0" | 200 lbs | - |
| Saint, Rusty | RP | Pulaski Yankees | 21 | 04/14/1982 | Tucson | USA | Right | Right | 5' 11" | 180 lbs | - |
| Salazar, Juan | RP | Johnson City Cardinals | 19 | 07/12/1984 | Santo Domingo | DOM | Right | Right | 5' 10" | 160 lbs | - |
| Salazar, Luis | 3B | Hampton Orioles | 18 | 06/13/1985 | Santo Domingo | DOM | Right | Right | 5' 10" | 175 lbs | - |
| Saldivar, Alfredo | SP | Reidsville Red Sox | 21 | 10/12/1982 | Monte Plata | DOM | Right | Right | 6' 7" | 220 lbs | - |
| Sallada, Ben | CF | Portsmouth Nationals | 21 | 08/16/1982 | New York | USA | Right | Right | 6' 2" | 190 lbs | - |
| Samedi, Alpha | C | Kingsport Mets | 22 | 11/04/1981 | Milwaukee | USA | Switch | Right | 6' 0" | 185 lbs | - |
| San Roman, Alfredo | RP | Fayetteville Indians | 21 | 05/08/1982 | Cumana | VEN | Left | Right | 6' 6" | 210 lbs | - |
| Schrader, Brad | 1B | Elizabethton Twins | 22 | 09/29/1981 | Lutz | USA | Right | Right | 6' 4" | 205 lbs | - |
| Schuett, Kevin | SP | Raleigh Cubs | 20 | 10/22/1983 | Dumfries | USA | Right | Right | 6' 6" | 215 lbs | - |
| Schutzhauer, Oktav | CF | Bluefield Blue Jays | 20 | 10/17/1983 | San Clemente | USA | Right | Left | 6' 2" | 195 lbs | - |
| Segura, Alfredo | CF | Fayetteville Indians | 20 | 02/26/1983 | Boston | USA | Right | Right | 6' 4" | 200 lbs | - |
| Segura, Juan | C | Johnson City Cardinals | 21 | 09/03/1982 | San Juan | PUR | Left | Right | 6' 3" | 210 lbs | - |
| Serrano, Humberto | 3B | Elizabethton Twins | 22 | 10/13/1981 | Bayamón | PUR | Right | Right | 6' 0" | 190 lbs | - |
| Serrano, Juan | RP | Free Agent | 21 | 12/18/1981 | Medellín | COL | Left | Left | 6' 5" | 190 lbs | - |
| Serrano, Luis | RF | Blue Ridge Bulldogs | 21 | 09/03/1982 | Santiago | DOM | Left | Left | 6' 3" | 205 lbs | - |
| Serrano, Sergio | 2B | Pulaski Yankees | 19 | 07/03/1984 | Puerto Plata | DOM | Switch | Right | 6' 2" | 185 lbs | - |
| Shattuck, Joel | 1B | Pulaski Yankees | 19 | 03/29/1984 | Long Beach | USA | Right | Right | 6' 1" | 180 lbs | - |
| Shaw, Kevin | 3B | Elizabethton Twins | 19 | 04/12/1984 | Ecorse | USA | Right | Right | 6' 0" | 180 lbs | - |
| Sheets, Dave | CF | Fayetteville Indians | 20 | 06/11/1983 | Madison | USA | Left | Left | 6' 1" | 185 lbs | - |
| Shelton, Ben | SP | Bluefield Blue Jays | 21 | 11/23/1981 | Huntington Station | USA | Left | Left | 5' 9" | 175 lbs | - |
| Silva, Jorge | RP | Hampton Orioles | 20 | 01/15/1983 | Baní | DOM | Right | Right | 6' 2" | 175 lbs | - |
| Simonson, Devon | RP | Danville Braves | 21 | 12/12/1981 | Montgomery Village | USA | Right | Left | 6' 0" | 185 lbs | - |
| Smithers, Jeremy | RP | Princeton Rays | 19 | 11/14/1983 | Macomb Township | USA | Left | Left | 6' 5" | 205 lbs | - |
| Smythers, Mike | C | Reidsville Red Sox | 21 | 12/09/1981 | Lauderhill | USA | Right | Right | 6' 3" | 205 lbs | - |
| Solorio, Juan | RP | Free Agent | 22 | 10/30/1981 | Cabimas | VEN | Right | Right | 6' 0" | 170 lbs | - |
| Sonnen, Vince | C | Reidsville Red Sox | 21 | 05/07/1982 | Seattle | USA | Right | Right | 6' 1" | 195 lbs | - |
| Sotelo, Jorge | SP | Elizabethton Twins | 18 | 11/13/1984 | Fajardo | PUR | Right | Right | 6' 2" | 185 lbs | - |
| Soto, Luis | CF | Reidsville Red Sox | 19 | 02/01/1984 | Maturín | VEN | Right | Right | 6' 2" | 185 lbs | - |
| Soto, Lupe | RP | Burlington Royals | 21 | 07/11/1982 | Hato Mayor | DOM | Right | Right | 6' 1" | 170 lbs | - |
| Stanley, Steve | 1B | Kingsport Mets | 21 | 12/18/1981 | Springdale | USA | Right | Right | 5' 11" | 195 lbs | - |
| Starratt, Camden | RP | Bluefield Blue Jays | 21 | 01/27/1982 | Quebec City | CAN | Left | Left | 6' 0" | 190 lbs | - |
| Stinney Jr., Phil | SP | Johnson City Cardinals | 21 | 11/25/1981 | Kennewick | USA | Right | Right | 6' 1" | 195 lbs | - |
| Strobel, Tim | RF | Princeton Rays | 21 | 01/11/1982 | Raymondville | USA | Right | Left | 6' 5" | 210 lbs | - |
| Struzinski, Steve | C | Reidsville Red Sox | 19 | 11/01/1984 | Los Angeles | USA | Left | Right | 5' 11" | 185 lbs | - |
